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HIV-1 Tat protein: sufficient to cause HIV-Associated Neurological Deficits (HAND)
Florida Health Grand Rounds
“HIV-1 Tat protein: sufficient to cause HIV-Associated Neurological Deficits (HAND)?”
November 8, 2016 at 10:00 AM ET
Presented by Dr. Jay McLaughlin
Associate Professor, University of Florida College of Pharmacy
Dr. McLaughlin will discuss data collected from research on the HIV regulatory protein, Tat, using transgenic mice. Findings will demonstrate the ability of Tat protein by itself to produce neurological effects characteristic of HIV-Associated Neurological Deficits (HAND), specifically increased drug seeking behaviors, decreased cognitive abilities, and the onset of mood disorders. Testing results with both novel and clinically approved pharmaceutics suggest potentially new therapeutic approaches to prevent Tat protein related deficits.
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