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PEP, or post-exposure prophylaxis, is an HIV-prevention strategy using anti-retroviral medications to prevent acquiring HIV following a possible exposure. If you think you’ve been exposed to HIV and are in need of PEP, please DO NOT email the Florida Department of Health's HIV/AIDS Section, as these are administrative offices. Instead, please contact your local hospital emergency room, urgent care clinic, or local county health department for PEP evaluation and treatment. You may also find local PEP providers using the PrEP/PEP Provider Locator Map.
To be effective, PEP must begin within 72 hours of exposure. A physician must determine what treatment is appropriate based on the nature of the exposure. PEP typically consists of 2–3 antiretroviral medications taken for 28 days. Starting PEP after a potential exposure does not guarantee HIV prevention, but the sooner PEP is started, the better. Every hour counts. Follow-up testing is important to determine if any next steps are needed.
Additional PEP information and resources are below.
PrEP (Pre-Exposure Prophylaxis)
PrEP is a comprehensive HIV prevention strategy that involves the daily oral use or bi-monthly injection of antiretroviral medications to reduce the risk of acquiring HIV. PrEP should be used along with other prevention methods to reduce the risk of other sexually transmitted infections and unwanted pregnancy.
Visit our PrEP Locator to find a PrEP or nPEP provider in Florida.
Ready, Set, PrEP
General Info and Enrollment
Ready, Set, PrEP is a new nationwide program led by the U.S. Department of Health and Human Services (HHS). The Ready, Set, PrEP program provides PrEP medications at no cost to individuals who qualify. Check eligibility requirements and enroll in the program at getyourprep.com. Health care providers can also use this site to enroll a patient.
Resources for Download/Print
Factsheets, posters, info cards, and social media content (Facebook, Twitter, and Instagram graphics) available for download to use and help spread the word about the benefits of PrEP medications and how to access the Ready, Set, PrEP program. Factsheets are available for consumers, health care professionals, and Indian Health Service. Content included in this toolkit may be customized and tailored to your needs. Questions about materials can be directed to ReadySetPrEP@hhs.gov.
PrEP Provider Resources
FloridaHealth PrEP provider toolkits, resource guides, posters and brochures are available upon request. Email DiseaseControl@flhealth.gov for info.
- AETC Guidelines for PrEP and PEP
- CDC Clinical Practice and Provider Guidelines
- NASTAD PrEP/PEP Access Microsite
- PrEP Clinical Trials - CDC
General Audience Resources
PEP—Additional Info and Resources
There are two types of PEP: 1) occupational PEP, for an exposure that happens in the workplace (such as a needle stick in a healthcare setting), and 2) non-occupational PEP (nPEP), for when someone is potentially exposed to HIV through sexual intercourse or injection drug use.
PEP Provider Resources
- Updated Guidelines for Antiretroviral Post-Exposure Prophylaxis After Sexual, Injection Drug Use, or Other Non-Occupational Exposure to HIV
- OSHA Fact Sheet
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