West Nile virus (WNV) is a mosquito-borne flavivirus that causes mild to severe illness. It was first identified in Uganda in 1937.

WNV was first introduced to the United States in 1999 in New York and reached Florida in 2001.  Since its initial detection, human cases of WNV have been reported in all U.S. states with the exception of Alaska and Hawaii. 

Each year, about 2,000 people in the U.S. are diagnosed with West Nile, but this number is an underestimate as most people do not develop symptoms or attribute mild symptoms to other causes.

Transmission
  • Most often, WNV is spread by the bite of an infected mosquito. Mosquitoes become infected when they feed on infected birds. Infected mosquitoes can then spread WNV to humans and other animals when they bite.
  • WNV is not spread through casual contact such as touching or kissing an infected person.

The peak period of transmission in Florida is July through September. Since its introduction, WNV activity has been identified in all 67 of Florida’s counties. After the 2003 peak, the number of human cases gradually decreased over the years from 2004 to 2009 until it started showing an increase in the number of cases in 2010.

The natural cycle of WNV involves several species of Culex mosquitoes and wild birds. It can cause high rates of mortality in certain families of birds, especially crows and jays. Occasionally, an infected mosquito will bite a human or animal (particularly horses) and cause disease. The virus can also be transmitted to humans through contaminated blood transfusions and a few cases have also been reported involving intrauterine transmission.  Since 2003, all blood donations are screened for the presence of WNV prior to transfusion.

Symptoms
  • Serious Symptoms. About one in 150 people infected with WNV will develop severe illness. The severe symptoms can include high fever, headache, neck stiffness, stupor, disorientation, coma, tremors, convulsions, muscle weakness, vision loss, numbness, and paralysis. These symptoms may last several weeks, and neurological effects may be permanent. Severe illness can also result in death.
  • Milder Symptoms. Up to 20% of the people who become infected have symptoms such as fever, headache, and body aches, nausea, vomiting, and sometimes swollen lymph glands or a skin rash on the chest, stomach and back. Symptoms can last from a few days to several weeks.
  • No Symptoms. Approximately 80% of people who are infected with WNV will not show any symptoms at all.

Most West Nile virus infections (approximately 80%) are asymptomatic. In those people that do develop symptoms, most experience a mild illness termed West Nile fever (WNF) that is characterized by headache, fever, pain, and fatigue. Symptoms typically appear between 2-14 days after the bite of an infected mosquito. 

Less than 1% of infected people develop the most severe form of disease, neuroinvasive WNV, which may involve meningitis and encephalitis and can cause irreversible neurological damage, paralysis, coma or death.

Individuals at Risk of Sever Illness

Serious illness can occur in people of any age. However, those over 60 years of age are at increased risk for severe disease.

People with certain medical conditions, such as cancer, diabetes, hypertension, kidney disease, and people who have received organ transplants or who have a weakened immune system, are also at greater risk for serious illness.

Testing

Talk to a health care provider if you think you or a loved one might have West Nile. Health care providers can order tests to look for West Nile virus infection or other infections that cause similar symptoms.

Treatment
  • There is no specific treatment for WNV infection.
  • In cases with milder symptoms, people experience symptoms such as fever and aches that pass on their own, although it may take several weeks to fully recover.
  • In more severe cases, people usually need to go to the hospital where they can receive supportive treatment including intravenous fluids, help with breathing and nursing care.
Prevention

The best way to protect yourself and your loved ones from West Nile virus is to prevent mosquito bites.

Surveillance and Data
Information for Health Care Providers